LUTATHERA® (lutetium Lu 177 dotatate) Treatment Journey

Trained Health Care Professionals Will Guide You
Through the Process

After your doctor has prescribed LUTATHERA, you will be referred to a treatment site where trained health care professionals will guide you through the ongoing process.

Starting LUTATHERA May Be an Important Step Forward

It’s important to tell your health care professional everything about your disease and health status. Health information you may want to discuss includes:

Any medical conditions you may have
Symptoms you may have
Any changes in your daily habits
If you have trouble controlling when you urinate or have a bowel movement
All of the medicines you are taking, including over-the-counter medicines
If you are trying to get pregnant, if you are already pregnant, or if you are breastfeeding

Make sure to let your health care professional know if you are taking either a type of medicine called a somatostatin analog, also called an SSA, and/or glucocorticoids. If you are taking either, you might have to stop or change your treatment before and while receiving LUTATHERA.

If you are a female who is able to get pregnant, use effective contraception during treatment with LUTATHERA and for 7 months after the last dose
If you are a male with a female partner who is able to get pregnant, use effective contraception during treatment with LUTATHERA and for 4 months after the last dose
Women should not breastfeed during treatment with LUTATHERA and for 2.5 months after the last dose

Your Journey Before Starting LUTATHERA
At Least 4 Weeks Before Starting LUTATHERA
	You will stop receiving a monthly, long-acting SSA, and your doctor might administer short-acting octreotide as needed to control symptoms

Before Starting First Treatment With LUTATHERA
	An imaging test will be performed to localize the tumor. Your health care professional may also perform some blood tests and other tests to evaluate your kidneys, liver, and blood Pregnancy status will be verified before starting LUTATHERA, because it has the potential to cause fetal harm

Up to 24 Hours Before Starting LUTATHERA
	Your health care professional might administer short-acting octreotide as needed for symptom management, but will discontinue at least 24 hours before your treatment with LUTATHERA

Your Journey While Receiving LUTATHERA

Day of Treatment With LUTATHERA

You will be given 2 medicines before your LUTATHERA infusion:

Medication, such as an antiemetic, intended to help with vomiting or an upset stomach that you may experience because of the treatment.
Intravenous (IV) sterile amino acid solution to help protect your kidneys. This infusion will start 30 minutes before your treatment with LUTATHERA and will last for the duration of your treatment, and for at least 3 hours after it has been completed.

The IV infusion of LUTATHERA will take approximately 30 to 40 minutes

- Because treatment with LUTATHERA uses radiation, you will have to wait a while before you can leave the treatment center. A health care professional will let you know when it's okay for you to leave the treatment center

During treatment with LUTATHERA, 30 mg of long-acting octreotide will be administered intramuscularly (IM) between 4 to 24 hours after each dose of LUTATHERA. Long-acting octreotide should not be given within 4 weeks before each subsequent dose of LUTATHERA. Short-acting octreotide may be given for symptom management during treatment with LUTATHERA, but must be withheld for at least 24 hours before each dose of LUTATHERA

Subsequent Treatments With LUTATHERA

You may receive LUTATHERA up to 3 more times after your first infusion. These doses will be between 8 and 16 weeks apart, depending on how you may tolerate the medication
Your health care professional will decide how many doses and how long between each dose is right for you

- Tests evaluating your liver, kidneys, and blood may be conducted again

After Last Treatment With LUTATHERA
	After your last dose of LUTATHERA, tests evaluating your liver, kidneys, and blood may be conducted again You may continue receiving 30 mg of long-acting octreotide every 4 weeks for 18 months after starting treatment with LUTATHERA depending on your health care professional's instructions, or until your cancer starts to spread or get worse